Paroxysmal nocturnal hemoglobinuria (PNH)
What is PNH?
PNH is a rare, chronic, progressive and potentially life-threatening blood disorder characterized by red blood cell destruction within blood vessels (also known as intravascular hemolysis, or IVH) and white blood cell and platelet activation, which may lead to blood clots (thrombosis).
Thrombosis can occur in blood vessels throughout the body, and/or damage to other vital organs, such as the kidneys and lungs. This can result in an overall impaired quality of life and potentially premature death.1-3
PNH affects people of all races and ethnicities and can occur in men, women and children at any age, with an average age of diagnosis in the 30s.3
Joe, living with PNH
PNH Symptoms
PNH symptoms may include: 3
Shortness of breath
Abdominal pain
Dark-colored urine (hemoglobinuria)
Anemia
Blood clots (thrombosis)
Excessive fatigue
Erectile dysfunction
Now I know that others can benefit from my experience, and I want to be an inspiration to them."Victor
Living with PNH
References
- Jang JH, et al. Impact of lactate dehydrogenase and hemoglobin levels on clinical outcomes in patients with paroxysmal nocturnal hemoglobinuria: results from a Korean PNH registry. J Korean Med Sci. 2024;39(8):e81.
- Rother RP, et al. The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin. JAMA. 2005;293(13):1653-1662.
- Shah N, et al. Paroxysmal nocturnal hemoglobinuria. StatPearls. 2023.
Veeva ID: US/UNB-P/0500